The Effects of TGF-ß3, 17-ß Estradiol and Bisphenol A on Osteoprotegerin Production in Osteoblasts
نویسندگان
چکیده
Kemik metabolizması hem fizyolojik de patolojik durumlarda karmaşık ve zorlu bir konudur. Dokunun homeostazisi büyük oranda osteoblastların osteoklastların karşılıklı aktiviteleri ile idare edilmektedir. Osteoprotegerin (OPG), başlıca osteoblastlar tarafından üretilen RANKL bağlanarak osteoklast farklılaşmasının inhibe edilmesini sağlayan tuzak reseptördür. OPG seviyesindeki düşüş yoğun aktivasyonuna dolayısı yeni kemik yapımını aşan miktarda yıkımına sebep olmaktadır. Bu nedenle üretim mekanizmasını anlamak OPG’nin düzenleyicilerini identifiye etmek önem arz etmektedir. çalışmada TGF-ß3, 17-ß estradiol endokrin bozucu olan bisfenol A’nın (BPA) osteoblastlardan üretimine etkilerinin belirlenmesi amaçlandı. amaçla hfOB hücrelerine BPA 48 saat boyunca tek başlarına kombinasyon halinde uygulandı. faktörlerin etkileri sandviç ELISA yöntemi değerlendirildi. Yapılan analizde TGF-ß3 estradiolün kullanımının seviyelerinde artış sağladığı belirlendi. Ayrıca, BPA’nın üretimi üzerine antagonistik etkilerini birlikte uygulandığında gösterdiği gözlendi.
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ژورنال
عنوان ژورنال: Kocatepe veteriner dergisi
سال: 2021
ISSN: ['1308-1594']
DOI: https://doi.org/10.30607/kvj.889086